ABSTRACT
In the process of designing genechip probe for detecting pathogenic microorganism, the selection of single nucleotide polymorphism (SNP) combination is of great importance. At present, there is no automatic design method. This work is hard and the result is not always well. A new approach for selecting SNP combination is presented in this paper. Genetic algorithm is used to search optimal solution on the basis of classification ability of SNP combination, which is evaluated by the rough set theory. Other related experimental parameters are also incorporated. Experimental results show that the method can find out the best SNP combination pattern efficiently and accurately, thus demonstrating the reliability of this new method for designing the genechip probe.
Subject(s)
Humans , Algorithms , Base Sequence , Brucella , Molecular Sequence Data , Oligonucleotide Array Sequence Analysis , Methods , Polymorphism, Single Nucleotide , Salmonella entericaABSTRACT
In this paper a filtering method for EECG (Exercise ECG) signal is proposed which is based on wavelet transform (WT) and Stein's unbiased risk estimate (SURE). This algorithm was used to decompose original EECG signals into detail signals on different frequency bands by using WT and get different thresholds with SURE. According to EECG signal features and by using the above thresholds, the method amended several detail signals so that the main interferences in EECG signal can be removed efficiently. The authors also put forward two indexes to estimate the validity of such algorithms. Our experimental results demonstrate that this is an efficient de-noising method for EECG.
Subject(s)
Humans , Algorithms , Echocardiography, Stress , Electrocardiography , Methods , Exercise Test , Methods , Signal Processing, Computer-AssistedABSTRACT
Bovine spongiform encephalopathy (BSE) is an infectious disease which can threaten animal husbandry and human health seriously. The disease mainly violates the central neural system. This article selectively reviewed current researches on the analytical detection of BSE and transmissible spongiform encephalopathy (TSE).
Subject(s)
Animals , Cattle , Humans , Encephalopathy, Bovine Spongiform , Diagnosis , Virology , PrionsABSTRACT
This pap er introduces something of photodynamic therapy including the basic principles,pho tosensitizers and recent situation of clinical trial.Its light source,research and clinical applications to malignant tumors are also presented.
ABSTRACT
Phonocardiogram exercise testing(PCGET) is a recently developed method for evaluating cardiac contractility and the cardiac reserve of patients with heart disease and of healthy subjects. In order to test the reliability of PCGET method in physical sport, the present author conducted a clinical study. The ratio of the amplitude of the first heart sound after PCGET to that recorded at rest was defined as an indicator, i.e. cardiac contractility reserve index (CCRI). PCGET was performed on 30 athletes and 30 non-athletes. The results showed that the average of CCRI was 10.139 +/- 2.631 in 30 athletes and 6.612 +/- 3.104 in 30 non-athletes. There was a significant difference between CCRI of the two groups (P < 0.01). Thus, PCGET might be a noninvasive, convenient and inexpensive technique to evaluate the cardiac reserve quantitatively for athletes.